A recent study that included NDRI-sourced tissue to examine how Alzheimer’s disease affects the retina has been featured in a segment on CNN health. The study, lead by Dr. Maya Koronyo-Hamaoui, a professor of neurosurgery and biomedical sciences at Cedars-Sinai in Los Angeles, aimed to identify molecular, cellular, and structural changes in the retina that may indicate early cognitive decline. Investigators in the study collected retinal and brain tissue samples over 14 years from 86 human donors with Alzheimer’s disease, the largest group of retinal samples every studied.
The study, published in journal Acta Neuropathologica, found significant increases in key markers like beta-amyloid and a decline in Microglial cells, both important indicators of cognitive decline. Their findings indicate that new eye tests may provide doctors with a noninvasive way to diagnose Alzheimer’s disease early and more accurately. Check out the link to the article below and visit the publications page on our website to see more ways investigators are using human tissue to make an impact and advance disease research.